Sputum and blood concentrations of cefuroxime in lower respiratory tract infection.

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Sputum and blood concentrations of cefuroxime in lower respiratory tract infection.

A detailed pharmacokinetic study of cefuroxime has been carried out. Levels of cefuroxime were determined in the blood, sputum, saliva, and urine of 23 patients receiving parenteral cefuroxime eight hourly for chest infections. Profiles were obtained after the first dose and on the final (fifth) day of treatment. Antibiotic levels in the sputum reached 0.8 mg/l within one hour of the first inje...

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Cryptosporial and bacterial co-infection is reported in a budgerigar with clinical manifestations of septicemia and respiratory tract infection. Microscopically large number of round to oval 2-5μm cryptosporidial organisms were found to be lodged on the parabronchial epithelial cells of the respiratory tract. The bacterial colonies were seen around the parabronchial spaces of the lung tissue. I...

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Acute lower respiratory tract infection.

Copyright © 2008 Massachusetts Medical Society. A cute lower respiratory tract infections are a persistent and pervasive public health problem. They cause a greater burden of disease worldwide than human immunodeficiency virus infection, malaria, cancer, or heart attacks.1 In the United States, they cause more disease and death than any other infection, and there has been little change in morta...

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Improving the use of sputum cultures in lower respiratory tract infection.

BACKGROUND The clinical value of sputum culture in suspected lower respiratory tract infection (LRTI) remains contentious. The quality of samples submitted significantly impacts their clinical usefulness. METHODS Using pre-defined criteria we prospectively analysed the appropriateness of sputum samples submitted from consecutive patients with suspected LRTI attending two acute hospital units ...

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We investigated whether discoloured sputum and feeling unwell were associated with antibiotic prescription and benefit from antibiotic treatment for acute cough/lower respiratory tract infection (LTRI) in a prospective study of 3,402 adults in 13 countries. A two-level model investigated the association between producing discoloured sputum or feeling generally unwell and an antibiotic prescript...

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ژورنال

عنوان ژورنال: Thorax

سال: 1980

ISSN: 0040-6376

DOI: 10.1136/thx.35.5.379